Wearing gloves, wash jalapenos. Trim off stem, cut in half lengthwise, and remove seeds and veins. Place on a paper towel to dry completely.
Combine softened cream cheese and shredded cheddar until fully creamed together. Add a little bit of garlic powder if desired.
Spread a big spoonful (1 Tablespoon +) into each jalapeno half.
Wrap with a slice of bacon and secure with toothpick.
Arrange half of the poppers in your air fryer (or all of them, if space allows) in a single layer and cook at 370°. Check at 6 minutes. Continue another 4 minutes if they aren't crispy yet.
Option: Rotate out the first batch after 6 minutes. Cook the second batch for 6 minutes, and then trade again, going another 4 minutes, with each batch. This way, you are able to serve all of the poppers at once.